This episode will discuss the development of intensified T-cell acute lymphoblastic leukemia-focused protocols, the use of a thrombopoietin agonist for thrombocytopenia following allogeneic hematopoieticstem cell transplantation, and a crucial step forward in the development of miRNA therapies targeting myeloid diseases.
How I Treat Newly Diagnosed T-cell Acute Lymphoblastic Leukemia and T-cell Lymphoblastic Lymphoma in Children
Historically, these aggressive T-cell malignancies have carried poor prognoses. Teachey and O’Connor use 3 cases to illustrate how excellent outcomes can now be expected for the majority of children using the same regimens for both diseases. They tackle issues around indications for allogeneic stem cell transplantation and cranial radiation, the use of nelarabine, and whether to use different regimens for early T-cell precursor acute lympoblastic leukemia.
Myeloid Cell-Targeted miR-146a Mimic Inhibits NF-kB-Driven Inflammation and Leukemia Progression in Vivo
Dual targeting of both the cell of interest and the molecular driver is a holy grail of precision therapeutics. In this preclinical proof-of-principle article, Su et al demonstrate that NF-κB–driven cytokine release syndrome and preclinical models of myeloid malignancy can be achieved using a synthetic microRNA mimic conjugated to a scavenger receptor agonist.
Wdr26, a gene upregulated during terminal erythropoiesis, encodes a core subunit of the glucose-induced degradation-deficient ubiquitin ligase complex. Zhen et al reveal its essential role in a pathway for nuclear opening formation, nuclear condensation, and enucleation during terminal erythropoiesis.
About 20% of follicular lymphomas present as localized-stage disease. Intriguingly, only half carry t(14;18). Staiger and colleagues have identified distinct gene expression signatures that distinguish localized-stage from advanced-stage disease, providing insights into the biological difference between these subgroups.
The use of peripherally inserted central catheters (PICCs) in children has increased due to ease of placement compared to tunneled lines and the thought that PICCs have fewer associated adverse events. This month’s CME article reports on the largest prospective observational study of long-term central venous catheter–related complications in children to date, in which this dogma is overturned. The research provides important information for decision-making about when to use central catheters and which type to choose.