Issue Archive

Edited by Associate Editor Berthold Göttgens, this Review Series focuses on how the use of single-cell genomic and multiomic analyses are broadening our understanding of the complexity of leukemias and myeloid neoplasms. For acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, and myeloproliferative neoplasm, leading experts bring us up to date with recent data and speculate how these rapidly developing technologies may inform the directions of clinical care.

Chronic hyperviscosity anemia and compensatory vasodilation predispose to recurrent cerebral infarction in patients with sickle cell disease (SCD). In this Plenary Paper, Hulbert and colleagues report on a detailed study of cerebral hemodynamics before and after allogeneic stem cell transplant, demonstrating normalization of preexisting SCD-related blood flow and oxygenation defects beyond what is achievable with chronic transfusion therapy. Stem cell transplants may provide greater stroke protection than chronic transfusion therapy.

Edited by Associate Editor Berthold Göttgens, this Review Series focuses on how the use of single-cell genomic and multiomic analyses are broadening our understanding of the complexity of leukemias and myeloid neoplasms. For acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, and myeloproliferative neoplasm, leading experts bring us up to date with recent data and speculate how these rapidly developing technologies may inform the directions of clinical care.

Edited by Associate Editor Berthold Göttgens, this Review Series focuses on how the use of single-cell genomic and multiomic analyses are broadening our understanding of the complexity of leukemias and myeloid neoplasms. For acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, and myeloproliferative neoplasm, leading experts bring us up to date with recent data and speculate how these rapidly developing technologies may inform the directions of clinical care.

Edited by Associate Editor Berthold Göttgens, this Review Series focuses on how the use of single-cell genomic and multiomic analyses are broadening our understanding of the complexity of leukemias and myeloid neoplasms. For acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, and myeloproliferative neoplasm, leading experts bring us up to date with recent data and speculate how these rapidly developing technologies may inform the directions of clinical care.

Edited by Associate Editor Berthold Göttgens, this Review Series focuses on how the use of single-cell genomic and multiomic analyses are broadening our understanding of the complexity of leukemias and myeloid neoplasms. For acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, and myeloproliferative neoplasm, leading experts bring us up to date with recent data and speculate how these rapidly developing technologies may inform the directions of clinical care.

Long noncoding RNAs (lncRNA) regulate cellular functions in tissue- and cell-type specific fashions. Morelli et al show that a novel lncRNA, RNA regulator of lipogenesis (RROL), encoded by the MIR17HG gene, acts as a chromatin scaffold for protein interaction, enhancing the growth of multiple myeloma cells. RROL inhibition exhibits potent antimyeloma activity in vitro and in multiple in vivo models, suggesting it may have therapeutic potential.

Genetic mutations affecting glycosylation can contribute to abnormal platelet production and function. In this context, Marín-Quílez and colleagues characterize the functions of UDP-galactose-4-epimerase (GALE), identifying 3 new GALE mutations in patients with macrothrombocytopenia, and moderate-to-severe bleeding tendencies. The authors explain their phenotypic effects on platelet production, structure, and function through elegant mechanistic studies.

Hepcidin is the master regulator of systemic iron homeostasis. Using genetically manipulated murine models, Xiao and colleagues reveal that hepatocyte transferrin receptor 1 (TfR1) restrains hepcidin induction by serum iron and promotes hepcidin suppression and iron overload in β-thalassemia. The authors prove that TfR1 action is dependent upon HFE, the product of the most commonly mutated gene in hereditary hemochromatosis, adding important detail to our knowledge of iron regulation.

Mutations in the nucleophosmin 1 gene (NPM1) occur frequently in acute myeloid leukemia (AML) and are associated with a favorable prognosis. Applying the new 2022 European LeukemiaNet (ELN) classifier, Angenendt et al tested the prognostic significance of the copresence of NPM1 mutations and adverse-risk cytogenetics among 2426 patients. The authors demonstrate that outcomes for cytogenetic adverse-risk AML are not modulated by the presence or absence of NPM1 mutations, thereby clarifying management for patients.