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Issue Archive

Volume 7, Issue 4
February 28 2023
Issue Cover

Table of Contents

STIMULUS REPORTS

Doxorubicin pharmacokinetics and toxicity in patients with aggressive lymphoma and hepatic impairment
Clinical Trials & Observations
Catherine Lai,Diane E. Cole,Seth M. Steinberg,Nicole Lucas,Eva Dombi,Christopher Melani,Mark Roschewski,Frank Balis,Brigitte C. Widemann,Wyndham H. Wilson
View Articletitled, Doxorubicin pharmacokinetics and toxicity in patients with aggressive lymphoma and hepatic impairment
Supplemental data
Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies
Caner Saygin,Gregory Roloff,Christopher N. Hahn,Rakchha Chhetri,Saar Gill,Hany Elmariah,Chetasi Talati,Emma Nunley,Guimin Gao,Aelin Kim,Michael Bishop,Satyajit Kosuri,Soma Das,Deepak Singhal,Parvathy Venugopal,Claire C. Homan,Anna Brown,Hamish S. Scott,Devendra Hiwase,Lucy A. Godley
View Articletitled, Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies
Supplemental data
Hematopoietic stem cell boost for persistent neutropenia after CAR T-cell therapy: a GLA/DRST study
Clinical Trials & Observations
Nico Gagelmann,Gerald Georg Wulf,Johannes Duell,Bertram Glass,Pearl van Heteren,Bastian von Tresckow,Monika Fischer,Olaf Penack,Francis Ayuk,Herrmann Einsele,Udo Holtick,Julia Thomson,Peter Dreger,Nicolaus Kröger
View Articletitled, Hematopoietic stem cell boost for persistent neutropenia after CAR T-cell therapy: a GLA/DRST study
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Ibrutinib plus RICE or RVICI for relapsed/refractory mature B-cell non-Hodgkin lymphoma in children and young adults: SPARKLE trial
Clinical Trials & Observations
G. A. Amos Burke,Luciana Vinti,Edita Kabickova,Auke Beishuizen,Nurdan Tacyildiz,Anne Uyttebroeck,Hyoung Jin Kang,Flavio Luisi,Véronique Minard-Colin,Birgit Burkhardt,Monelle Tamegnon,Steven Sun,Madeliene Curtis,Sanjay Deshpande,Kerri Nottage,Angela Howes,Srimathi Srinivasan,Deepa Bhojwani,Robin Norris,Mitchell Cairo
View Articletitled, Ibrutinib plus RICE or RVICI for relapsed/refractory mature B-cell non-Hodgkin lymphoma in children and young adults: SPARKLE trial
Supplemental data
Deferiprone for transfusional iron overload in sickle cell disease and other anemias: open-label study of up to 3 years
Clinical Trials & Observations
Mohsen S. Elalfy,Mona Hamdy,Amal El-Beshlawy,Fatma S. E. Ebeid,Mohamed Badr,Julie Kanter,Baba Inusa,Amira A. M. Adly,Suzan Williams,Yurdanur Kilinc,David Lee,Caroline Fradette,Anna Rozova,Noemi Toiber Temin,Fernando Tricta,Janet L. Kwiatkowski
View Articletitled, Deferiprone for transfusional iron overload in sickle cell disease and other anemias: open-label study of up to 3 years
Supplemental data
The safety and efficacy of N8-GP (turoctocog alfa pegol) in previously untreated pediatric patients with hemophilia A
Clinical Trials & Observations
Christoph Male,Christoph Königs,Sohan Dey,Tadashi Matsushita,Anders Holm Millner,Marek Zak,Guy Young,Gili Kenet
View Articletitled, The safety and efficacy of N8-GP (turoctocog alfa pegol) in previously untreated pediatric patients with hemophilia A
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Disruption of stem cell niche–confined R-spondin 3 expression leads to impaired hematopoiesis
Antonina V. Kurtova,Melanie Heinlein,Simon Haas,Lars Velten,Gerrit J. P. Dijkgraaf,Elaine E. Storm,Noelyn M. Kljavin,Soufiane Boumahdi,Patricia Himmels,Aurelie Herault,Andrew Mancini,Hartmut Koeppen,Monique Dail,Qingxiang Yan,Jianhuan Zhang,Ute Koch,Freddy Radtke,Zora Modrusan,Ciara Metcalfe,Robert Piskol,Frederic J. de Sauvage
View Articletitled, Disruption of stem cell niche–confined R-spondin 3 expression leads to impaired hematopoiesis
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Higher doses of tisagenlecleucel are associated with improved outcomes: a report from the pediatric real-world CAR consortium
Heather E. Stefanski,Anne Eaton,Christina Baggott,Jenna Rossoff,Michael R. Verneris,Snehit Prabhu,Holly L. Pacenta,Christine L. Phillips,Julie-An Talano,Amy Moskop,Steven P. Margossian,Gary Douglas Myers,Nicole A. Karras,Patrick A. Brown,Muna Qayed,Michelle Hermiston,Prakash Satwani,M. Christa Krupski,Amy K. Keating,Rachel Wilcox,Cara A. Rabik,Vanessa A. Fabrizio,Vasant Chinnabhandar,A. Yasemin Goksenin,Kevin J. Curran,Crystal L. Mackall,Theodore W. Laetsch,Liora M. Schultz
View Articletitled, Higher doses of tisagenlecleucel are associated with improved outcomes: a report from the pediatric real-world CAR consortium
Supplemental data
Preinfusion factors impacting relapse immunophenotype following CD19 CAR T cells
Adam J. Lamble,Regina M. Myers,Agne Taraseviciute,Samuel John,Bonnie Yates,Seth M. Steinberg,Jennifer Sheppard,Alexandra E. Kovach,Brent Wood,Michael J. Borowitz,Maryalice Stetler-Stevenson,Constance M. Yuan,Vinodh Pillai,Toni Foley,Perry Chung,Lee Chen,Daniel W. Lee,Colleen Annesley,Amanda DiNofia,Stephan A. Grupp,Michael R. Verneris,Lia Gore,Theodore W. Laetsch,Deepa Bhojwani,Patrick A. Brown,Michael A. Pulsipher,Susan R. Rheingold,Rebecca A. Gardner,Nirali N. Shah
View Articletitled, Preinfusion factors impacting relapse immunophenotype following CD19 CAR T cells
Supplemental data

LYMPHOID NEOPLASIA

SUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma
Guus J. J. E. Heynen,Francis Baumgartner,Michael Heider,Upayan Patra,Maximilian Holz,Jan Braune,Melanie Kaiser,Isabell Schäffer,Stefanos A. Bamopoulos,Evelyn Ramberger,Arunima Murgai,Yuen Lam Dora Ng,Uta Margareta Demel,Dominik Laue,Sven Liebig,Josefine Krüger,Martin Janz,Axel Nogai,Markus Schick,Philipp Mertins,Stefan Müller,Florian Bassermann,Jan Krönke,Ulrich Keller,Matthias Wirth
View Articletitled, SUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma
Supplemental data
Peripheral blood monocyte count is a dynamic prognostic biomarker in multiple myeloma
Clinical Trials & Observations
Camille V. Edwards,Hamza Hassan,Cenk Yildirim,Grace Ferri,Karina P. Verma,Mara E. Murray Horwitz,Nathanael R. Fillmore,Nikhil C. Munshi
View Articletitled, Peripheral blood monocyte count is a dynamic prognostic biomarker in multiple myeloma
Supplemental data
EMD originates from hyaluronan-induced homophilic interactions of CD44 variant-expressing MM cells under shear stress
Jiro Kikuchi,Nobuyuki Kodama,Masataka Takeshita,Sho Ikeda,Takahiro Kobayashi,Yoshiaki Kuroda,Michihiro Uchiyama,Naoki Osada,Bjarne Bogen,Hiroshi Yasui,Naoto Takahashi,Akiyoshi Miwa,Yusuke Furukawa
View Articletitled, EMD originates from hyaluronan-induced homophilic interactions of CD44 variant-expressing MM cells under shear stress
Supplemental data
Gene expression profiling and FDG-PET radiomics uncover radiometabolic signatures associated with outcome in DLBCL
Saveria Mazzara,Laura Travaini,Francesca Botta,Chiara Granata,Giovanna Motta,Federica Melle,Stefano Fiori,Valentina Tabanelli,Anna Vanazzi,Safaa Ramadan,Tommaso Radice,Sara Raimondi,Giuliana Lo Presti,Mahila E. Ferrari,Barbara Alicja Jereczek-Fossa,Corrado Tarella,Francesco Ceci,Stefano Pileri,Enrico Derenzini
View Articletitled, Gene expression profiling and FDG-PET radiomics uncover radiometabolic signatures associated with outcome in DLBCL
Supplemental data

MYELOID NEOPLASIA

Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study
Clinical Trials & Observations
Paul G. Kemps,Timo C. E. Zondag,Helga B. Arnardóttir,Nienke Solleveld-Westerink,Jelske Borst,Eline C. Steenwijk,Demi van Egmond,Joost F. Swennenhuis,Ellen Stelloo,Irene Trambusti,Robert M. Verdijk,Carel J. M. van Noesel,Arjen H. G. Cleven,Marijn A. Scheijde-Vermeulen,Marco J. Koudijs,Lenka Krsková,Cynthia Hawkins,R. Maarten Egeler,Jesper Brok,Tatiana von Bahr Greenwood,Karel Svojgr,Auke Beishuizen,Jan A. M. van Laar,Ulrike Pötschger,Caroline Hutter,Elena Sieni,Milen Minkov,Oussama Abla,Tom van Wezel,Cor van den Bos,Astrid G. S. van Halteren
View Articletitled, Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

RNA-regulatory exosome complex suppresses an apoptotic program to confer erythroid progenitor cell survival in vivo
Isabela Fraga de Andrade,Kirby D. Johnson,Charu Mehta,Colin N. Dewey,Uttiya Basu,Emery H. Bresnick
View Articletitled, RNA-regulatory exosome complex suppresses an apoptotic program to confer erythroid progenitor cell survival in vivo
Supplemental data
Elucidating parasite and host-cell factors enabling Babesia infection in sickle red cells under hypoxic/hyperoxic conditions
Divya Beri,Manpreet Singh,Marilis Rodriguez,Mihaela Barbu-Stevanovic,Giselle Rasquinha,Avital Mendelson,Xiuli An,Deepa Manwani,Karina Yazdanbakhsh,Cheryl A. Lobo
View Articletitled, Elucidating parasite and host-cell factors enabling <em>Babesia</em> infection in sickle red cells under hypoxic/hyperoxic conditions
Supplemental data

THROMBOSIS AND HEMOSTASIS

Platelet-targeted thrombolysis for treatment of acute ischemic stroke
Jason S. Palazzolo,Anukreity Ale,Heidi Ho,Shweta Jagdale,Brad R. S. Broughton,Robert L. Medcalf,David K. Wright,Karen Alt,Christoph E. Hagemeyer,Be’eri Niego
View Articletitled, Platelet-targeted thrombolysis for treatment of acute ischemic stroke
Supplemental data

RESEARCH LETTERS

Ibrutinib in patients over 80 years old with CLL: a multicenter Italian cohort
Gianluigi Reda,Veronica Mattiello,Anna Maria Frustaci,Andrea Visentin,Francesca Romana Mauro,Idanna Innocenti,Massimo Gentile,Diana Giannarelli,Alessandro Noto,Ramona Cassin,Antonino Neri,Luca Laurenti,Alessandra Tedeschi
View Articletitled, Ibrutinib in patients over 80 years old with CLL: a multicenter Italian cohort
Supplemental data
Interferon-γ blockade in CAR T-cell therapy–associated macrophage activation syndrome/hemophagocytic lymphohistiocytosis
Clinical Trials & Observations
Michael Rainone,Dat Ngo,John H. Baird,L. Elizabeth Budde,Myo Htut,Ibrahim Aldoss,Vinod Pullarkat
View Articletitled, Interferon-γ blockade in CAR T-cell therapy–associated macrophage activation syndrome/hemophagocytic lymphohistiocytosis
Prolonged thrombocytopenia after CAR T-cell therapy: the role of thrombopoietin receptor agonists
Clinical Trials & Observations
Gaëlle Drillet,Faustine Lhomme,Sophie De Guibert,Guillaume Manson,Roch Houot
View Articletitled, Prolonged thrombocytopenia after CAR T-cell therapy: the role of thrombopoietin receptor agonists
Supplemental data
Effects of teclistamab and talquetamab on soluble BCMA levels in patients with relapsed/refractory multiple myeloma
Clinical Trials & Observations
Suzette Girgis,Shun Xin Wang Lin,Kodandaram Pillarisetti,Raluca Verona,Diego Vieyra,Tineke Casneuf,Damien Fink,Xin Miao,Yang Chen,Tara Stephenson,Arnob Banerjee,Brandi W. Hilder,Jeffery Russell,Jeffrey Infante,Yusri Elsayed,Jennifer Smit,Jenna D. Goldberg
View Articletitled, Effects of teclistamab and talquetamab on soluble BCMA levels in patients with relapsed/refractory multiple myeloma
Supplemental data

ERRATUM

Jeong H, Cho H, Kim H, et al. Efficacy and safety of prophylactic high-dose MTX in high-risk DLBCL: a treatment intent–based analysis. Blood Adv. 2021;5(8):2142-2152.
View Articletitled, Jeong H, Cho H, Kim H, et al. Efficacy and safety of prophylactic high-dose MTX in high-risk DLBCL: a treatment intent–based analysis. <em>Blood Adv.</em> 2021;5(8):2142-2152.
  • Cover Image

    Cover Image

    issue cover

    Myeloma cells isolated from extramedullary lesions form cell clusters in culture with hyaluronic acid (HA) under shear stress. Clustered cells highly express the HA receptor CD44, whose engagement with HA was visualized by immunocytochemical staining with HA-binding protein (HABP). The binding of HA to surface CD44 might trigger the homophilic interaction of myeloma cells, which is enhanced by shear stress in the bone marrow microenvironment to serve as a seed of extramedullary disease. See the article by Kikuchi et al.

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Sahin I, Kawano Y, Sklavenitis-Pistofidis R, et al. Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma. Blood Adv. 2019;3(7):995-1002.
Jian Y, Chang L, Shi M-X, et al. Pomalidomide, bortezomib, and dexamethasone for newly diagnosed multiple myeloma patients with renal impairment. Blood Adv. 2023;7(24):7581-7584.
Tyrosine kinase inhibitor resistance in de novo BCR::ABL1–positive BCP-ALL beyond kinase domain mutations
Thrombotic events associated with low baseline direct oral anticoagulant levels in atrial fibrillation: the MAS study
In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function

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