Platelet count course for Clinical Case 1. Representative of a typical case in which TPO-RA support is necessary for adequate platelet count recovery to support many remaining chemotherapy cycles at full dose and on schedule after development of persistent CIT. Green zone represents goal platelet count on romiplostim, yellow zone represents CIT platelet count range resulting in dose reduction and/or treatment delay of chemotherapy, and red zone represents profound thrombocytopenia resulting in increased risk for bleeding.